Cover Image: E12.5 whole mouse embryo was immunostained with neurofilament antibody and cleared with RTF. Scale bar, 1000 μm. Used without modification under Creative Commons Attribution 4.0 International License from (Yu T. Z., 2018) Figure 4a. As explained in last...
Cover Image: Imaging of the whole-brain vasculatures at sub-cellular resolution. Brains of adult Tie2-Cre;tTAflox;tetO-H2BGFP (TTH) mice were cleared using the PEGASOS method and imaged with a tiling light-sheet microscope. g An X-Z optical slice acquired at the...
Biologists are very interested in how proteins, lipids and other compounds are organized and interact in systems. Very few organizational details can be gained by using standard transmission-based light microscopy, even when employing phase or other contrast-enhancing...
The cerebral cortex is between 2-4 millimeters thick depending on the region of the brain. In one cubic millimeter of human temporal cortex, there are 57,000 cells, 150 million synapses and 230 millimeters of blood vessels1. The typical thickness of a tissue slice for...
